2. Signaling Pathways
  3. GPCR/G Protein
  4. RXFP Receptor

RXFP Receptor

 
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-112606
    ML-290
    		99.81%
    ML-290 is a first-in-class and potent relaxin/insulin-like family peptide receptor (RXFP1) agonist and activator of anti-fibrotic genes, with an EC50 of 94 nM. ML290 is a biased allosteric agonist at the relaxin receptor RXFP1.
    ML-290
  • HY-148087
    AZD5462
    		99.88%
    AZD5462 is a RXFP1 modulator, can be used for heart failure research. RXFP1 is the cognate receptor for human relaxin, belongs to GPCR family 1c number with anti-fibrotic and anti-inflammatory properties.
    AZD5462
  • HY-145278
    RXFP3/4 agonist 2
    		99.82%
    RXFP3/4 agonist 2 is a potent, nonpeptide dual RXFP3/4 agonist (EC50=3.1 and 2.7 nM). RXFP3/4 agonist 2 also potently promotes interactions between RXFP3 and β-arrestin-2 with EC50 values in the range of 10-22 nM.
    RXFP3/4 agonist 2
  • HY-150186
    RXFP2 agonist 2
    RXFP2 agonist 2 is a selective，orally active and allosteric RXFP2 agonist with an EC50 value of 0.38 µM. RXFP2 agonist 2 induces osteoblast mineralization. RXFP2 agonist 2 increases bone formation in female mice. RXFP2 agonist 2 has the potential for the research of osteoporosis.
    RXFP2 agonist 2
  • HY-P4890A
    Relaxin H3 (human) (TFA)
    Relaxin H3 (human) (TFA) is a kind of relaxin peptide. Relaxin H3 (human) (TFA) exerts antifibrotic actions via RXFP1.
    Relaxin H3 (human) (TFA)
  • HY-P10687
    H3B10-27(13/17αF)
    H3B10-27(13/17αF) is an excellent scaffold for further developing reagent candidates and an important tool for understanding the physiological functions of the neuropeptide G protein-coupled receptor RXFP3, and it's very stable in serum.
    H3B10-27(13/17αF)
  • HY-P10728
    B7-33
    		Agonist
    B7-33 is a single-chain relaxin mimetic. B7-33 is a selective relaxin receptor 1 (RXFP1) agonist. B7-33 binds to RXFP1 and preferentially activates thepERK pathway over cAMP in cells (with RXFP1 expression). B7-33 is an anti-fibrotic agent. B7-33 has cardioprotective effects.
    B7-33
  • HY-111583
    RXFP3/4 agonist 1
    RXFP3/4 agonist 1 is an agonist of relaxin family peptide 3/4 receptor (RXFP3/4), with EC50s of 82/2 nM, respectivley. RXFP3/4 agonist 1 increases food intake in rats.
    RXFP3/4 agonist 1
  • HY-162401
    AZ7976
    		Agonist
    AZ7976 (Compound 42) is a highly selective agonist for the Relaxin Family Peptide Receptor 1 (RXFP1) (pEC50 > 10.5). AZ7976 enhances RXFP1's cAMP signaling through an allosteric mechanism, thereby physiologically increasing heart rate. AZ7976 can be used in the field of cardiovascular disease research.
    AZ7976
  • HY-156541
    RXFP1 receptor agonist-6
    RXFP1 receptor agonist-6 (Example 7) is a RXFP1 receptor agonist. RXFP1 receptor agonist-6 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC50 value of 12 nM.
    RXFP1 receptor agonist-6
  • HY-150185
    RXFP2 agonist 1
    RXFP2 agonist 1 (Compound 1715) is a potent RXFP2 agonist with an EC50 value of 0.06 µM. RXFP2 agonist 1 has the potential for the research of osteoporosis.
    RXFP2 agonist 1
  • HY-156543
    RXFP1 receptor agonist-8
    RXFP1 receptor agonist-8 (Example 2) is a RXFP1 receptor agonist. RXFP1 receptor agonist-8 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC50 value of 1.8 nM.
    RXFP1 receptor agonist-8
  • HY-145279
    RXFP3 agonist 1
    RXFP3 agonist 1 is a nonpeptide RXFP3 agonist (EC50=6937 nM).
    RXFP3 agonist 1
  • HY-156539
    RXFP1 receptor agonist-4
    RXFP1 receptor agonist-4 (Example 268) is a RXFP1 receptor agonist. RXFP1 receptor agonist-4 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC50 value of 4.9 nM.
    RXFP1 receptor agonist-4
  • HY-156536
    RXFP1 receptor agonist-1
    RXFP1 receptor agonist-1 (Example 2 peak2) is a RXFP1 receptor agonist. RXFP1 receptor agonist-1 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC50 value of 300 nM.
    RXFP1 receptor agonist-1
  • HY-156540
    RXFP1 receptor agonist-5
    RXFP1 receptor agonist-5 (Example 98) is a RXFP1 receptor agonist. RXFP1 receptor agonist-5 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC50 value of 1.3 nM.
    RXFP1 receptor agonist-5
  • HY-156538
    RXFP1 receptor agonist-3
    RXFP1 receptor agonist-3 (Example 223) is a RXFP1 receptor agonist. RXFP1 receptor agonist-3 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC50 value of 2 nM.
    RXFP1 receptor agonist-3
  • HY-P4890
    Relaxin H3 (human)
    Relaxin H3 (human) is a kind of relaxin peptide. Relaxin H3 (human) exerts antifibrotic actions via RXFP1.
    Relaxin H3 (human)
  • HY-156537
    RXFP1 receptor agonist-2
    RXFP1 receptor agonist-2 (Example 124) is a RXFP1 receptor agonist. RXFP1 receptor agonist-2 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC50 value of 1 nM.
    RXFP1 receptor agonist-2
  • HY-156542
    RXFP1 receptor agonist-7
    RXFP1 receptor agonist-7 (Example 2) is a RXFP1 receptor agonist. RXFP1 receptor agonist-7 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC50 value of 4.2 nM.
    RXFP1 receptor agonist-7
Cat. No. Product Name / Synonyms Application Reactivity